A Perspective on Robotics for Endomicroscopy

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I’ve recently co-authored a perspective called Robotics and Smart Instruments for Translating Endomicroscopy to In situ, In vivo Applications in the journal Computerized Medical Imaging and Graphics. The editorial discusses some of the challenges of in vivo confocal laser endomicroscopy (CLE), and how robotics technology may help to overcome them. This forms the basis for quite a lot of my current research so I would be interested to hear any comments or ideas people may have.

For those with access, the article is available online. Otherwise, a pre-print version is available here.

The full reference is:

Hughes, M. and Yang, G.-Z., Robotics and smart instruments for translating endomicroscopy to in situ, in vivo applications, Computerized Medical Imaging and Graphics, 36, p589 (2012)

3 Comments add one

  1. Graeme Mutton says:

    So you are fully informed as to Endomicroscopy more information is available at http://www.optiscan.com.au . Optiscan pioneered confocal microscopy and went on to develop the only other confocal endomicroscopy system in the world. The generation 1 system is licenced
    to Pentax and has been used in many clincal studies since 2006. It is used in many hospitals around the world including Johns Hopkins in the US. A generation 2 system has been developed for embedding into a flexible endoscope or as a stand alone probe. It has been incorporated into a rigid probe for Neurosurgery and is licenced to Carl Zeiss of Germany. Zeiss also have the licence for ENT.

    The system incorporates a single optical unlike the fibre bundle used by Mauna Kea.

    • Mike Hughes says:

      Thanks Graeme.

      I am broadly familiar with the first generation Optiscan/Pentax endomicroscope, although I’ve never actually used it. I’m planning on a post looking at distal scanning approaches to endomicroscopy, which will discuss the Optiscan device in more detail, sometime soon. As far as I can see at the moment, the main limitation of distal scanning is that it tends to lead to lower frame rates, which is a disadvantage for any kind of hand-held probe. The upside of course is the potential for higher resolution and avoidance of the large optical losses associated with fibre bundles. I’d be interested to hear your thoughts on the pros and cons from the point of view of an Optiscan advocate.

  2. Graeme Mutton says:

    This is the latest Optiscan presentation. When you come to comparisons re frame rates you will see that the Gen2 system is comparable with Cellvizio. I would note that faster frame rates aren`t necessarily an advantage when making a diagnosis.


    I would like to thank you for this forum that helps get the Endomicroscopy story out there. Reimbursement for procedures is available in the US from Jan 1st 2013 so I guess recognition of Patient and economic benefits are being recognised.

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