Posts from: April 2013

Capsule OCT Endomicroscopy

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A team from Massachusetts General Hospital (MGH) has developed a tethered endomicroscopy capsule, offering a potential alternative to endoscopic tissue biopsy. It uses optical coherence tomography (OCT) to generate high-resolution cross-sections through the walls of the oesophagus. Capsules are already in use for video endoscopy, and OCT has been shown to have value in the diagnosis of Barrett’s oesophagus, but this is the first time the two technologies have been combined.
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Cross Sectional Dual Axis Endomicroscopy

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When biopsies are reviewed by pathologists in histology, they are typically viewed in ‘cross-section’ – a slice is cut perpendicular to the surface of the tissue. In contrast, microscopy performed directly on the patient (in vivo or endomicroscopy) usually generates en face images – slices in the plane of the tissue surface. Some endomicroscopes designs allow vertical cross-sections to be generated from stacks of en face images at varying depths, but this is nowhere near to being a real time approach. A group from the University of Michigan has now developed a handheld endomicroscope which can generate vertical cross-sections with a frame rate of 10 Hz.
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